IL 6 ( interleukin 6 ( interferon beta 2 ) )

نویسندگان

  • Stefan Nagel
  • Roderick AF MacLeod
چکیده

Note: G/C polymorphism at nucleotide -174 (promoter region) Breast cancer prognosis differs between populations. Despite its lower incidence in Blacks when compared to Caucasians, mortality among the former is higher. Genetic factors involved in the molecular pathways regulating tumor development have been adduced to explain these differences, and it has been suggested that the IL-6 gene is a susceptibility factor underlying ethnic differences in breast cancer survival. Reports of a G/C polymorphism at nucleotide -174 within the promoter region of the IL-6 gene support this contention. This polymorphism modulates IL-6 expression and allele/genotype frequencies at the -174 site differ significantly between ethnic groups.

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تاریخ انتشار 2011